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Brand Names:

Contraindications:

Uses:

• This medicine, like all medicines used to treat cancer, is very strong. Make sure you understand why you are getting it and what the risks and benefits of treatment are. It is important for you to work closely with your doctor.
• Your doctor will prescribe your exact dose and tell you how often it will be given.
• Your medicine will be given through a tube put in one of your veins, usually in your arm, wrist, or hand and sometimes in the chest. This is called intravenous (in-tra-VEEN-us), or IV.
• A nurse or other care give trained to give cancer drugs will give your treatment.
• Drink at least 8 full glasses of liquid the day before and the day of receiving your medicine, and every day for 3 days afterward.
• Do not get the medicine on your skin. If it does, wash the area well with soap and water, and tell your caregiver.

• This medicine needs to be given on a regular schedule. If you miss a dose, call your doctor, home health caregiver, or clinic where you get your treatments for instructions.

Storage:

• If you have your treatments at a clinic, the staff at the clinic will keep your medicine there.
• If you have your treatments at home, you may need to store your medicine. Keep the medicine at room temperature, away from heat, moisture, and direct light.
• Any ifosfamide that has been mixed for an IV (mixed with other liquid) is good for 7 days at room temperature or 6 weeks if refrigerated. Keep the medicine in the refrigerator if possible, away from light and moisture.
• Throw away any unused medicine if the expiration date has passed.
• Keep all medicine out of the reach of children.
• If you have your treatments at home, you should be given a special container for the used needles, medicine bags or bottles, and tubes. Put it where children or pets cannot reach it.

Special precautions:

• Make sure your doctor knows if you are also taking allopurinol (Zyloprim®), chloral hydrate, phenobarbital, phenytoin (Dilantin®), cisplatin (Platinol®), corticosteroids, or succinylcholine.
• Talk to your doctor before getting any vaccines (such as flu shots) while receiving ifosfamide.

Warnings:

• Do not breastfeed if you are being treated with this medicine.
• Before using this medicine, tell your doctor if you have kidney problems, or if you have recently had other chemotherapy or radiation treatments.
• You may get infections more easily while you are getting ifosfamide. Stay away from crowds or people with colds, flu, or other infections.
• This medicine may make your mouth sore and irritated. Brush your teeth with a soft-bristle toothbrush or mouth swab.
• This medicine can cause nausea and vomiting. Your doctor may prescribe medicine to keep you from feeling sick and throwing up. If the medicine does not help (you can't keep liquids down), call your doctor.
• Do not get pregnant while you or your sexual partner are being treated with ifosfamide. Use an effective form of birth control while you are getting this medicine.
• If you are pregnant, talk to your doctor before you start your treatments.
• Some cancer drugs may make you sterile (unable to have children), whether you are a man or woman. If you plan to have children someday, talk with your doctor before you start your treatments.

Side Effects:

• Pain or burning when going to the bathroom (urinating)
• Bloody urine
• Unexplained fever, chills, or sore throat
• Unusual bleeding or bruising
• Extreme tiredness, dizziness
• Uncontrollable nausea, vomiting, or diarrhea
• Hair loss
• Upset stomach, loss of appetite
• Confusion
• Weakness, drowsiness, feeling tired