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Brand Names:

Contraindications:

Uses:

• This medicine, like all medicines used to treat cancer, is very strong. Make sure you understand why you are getting it and what the risks and benefits of treatment are. It is important for you to work closely with your doctor.
• You will receive this medicine while you are in a hospital or chemotherapy treatment center.
• This medicine is given before chemotherapy or radiation therapy. You may also receive other medicines to help prevent nausea and vomiting.
• Your medicine will be given directly into a vein, usually in your arm or chest. This is called intravenous (in-tra-VEEN-us), or IV.
• You will be watched closely for unwanted side effects while you are receiving this medicine.
• Drink plenty of fluids during the 24 hours before receiving this medicine.

Special precautions:

• Make sure your doctor knows if you are taking diuretics (water pills) or any other medicines for high blood pressure. Your doctor may tell you not to take these medicines for 24 hours before receiving amifostine.

Warnings:

• If you are pregnant or breastfeeding, talk to your doctor before you start your treatments.
• Be sure your doctor knows if you have a history of heart disease, stroke, or TIA (transient ischemic attack).
• This medicine causes nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
• Your doctor may want to check your blood. Be sure to keep all appointments.

Side Effects:

• Feeling faint
• Rash, hives, blisters, or peeling of skin
• Severe nausea and/or vomiting
• Sudden dizziness or lightheadedness
• Trouble breathing or swallowing
• Fever or chills
• Sleepiness